Introduction to basic concepts of Materials Science; Salient properties of important material classes; Property requirement of biomaterials; Concept of biocompatibility; Structure and properties of biological cells & tissues; cell-material interactions and foreign body response; Assessment of biocompatibility of biomaterials, in vitro biochemical assays (cellular adhesion, cellular viability using MTT, osteogenic differentiation using ALP assay; Biomnuneralisation using Osteocalcin assay);
In vivo testing and histocompatibility assessment; genotoxicity assessment (Physical damage to DNA by biomaterial eluates); important biometallic alloys: Ti-based, stainless steels, Co-Cr-Mo alloys; Bioinert, Bioactive and bioresorbable ceramics; Processing and properties of different bioceramic materials with emphasize on hydroxyapatite; synthesis of biocompatible coatings on structural implant materials; plasma spraying of carbon nanotube reinforced hydroxyapatite on Ti-6Al-4V substrate; Microstructure and properties of glass-ceramics; biodegradable polymers; Design concept of developing new materials for bio-implant applications.
Sl. No
Topic
Lecture Numbers
1.
Introduction to basic concepts of Materials Science; Salient properties of important material classes
1-3
2.
Property requirement of biomaterials; Concept of biocompatibility
4-5
3.
Structure and properties of biological cells & tissues
6-7
4.
Cell-material interactions and foreign body response
8-10
5.
Assessment of biocompatibility of biomaterials
11
6.
In vitro biochemical assays (cellular adhesion, cellular viability using MTT, osteogenic differentiation using ALP assay; Biomnuneralisation using Osteocalcin assay)
12-15
7.
In vivo testing and histocompatibility assessment
16-17
8.
Genotoxicity assessment (Physical damage to DNA by biomaterial eluates)
18
9.
Important biometallic alloys: Ti-based, stainless steels, Co-Cr-Mo alloys
19-21
10.
Bioinert, Bioactive and bioresorbable ceramics
22-24
11.
Processing and properties of different bioceramic materials with emphasize on hydroxyapatite
25-27
12.
Synthesis of biocompatible coatings on structural implant materials
28-29
13.
Plasma spraying of carbon nanotube reinforced hydroxyapatite on Ti-6Al-4V substrate; in-vitro cytocompatibility
30-32
14.
Microstructure and properties of glass-ceramics
33-34
15.
Biodegradable polymers
35-37
16.
Design concept of developing new materials for bio-implant applications
38-40
Biomaterials Science: An introduction to Materials in Medicine, Edited by Ratner, Hoffman, Schoet and Lemons, Second Edition: Elsevier Academic Press, 2004.
Biomaterials Science and Biocompatability, Fredrick H. Silver and David L. Christiansen, Piscataway, Springer, New Jersey.
Biological Performance of Materials: Fundamentals of Biocompatibility, Janathan Black, Marcel Dekker, Inc., New York and Basel, 1981.
Basic Cell Culture: A Practical Approach, Edited by J.M. Davis, IRL Press, Oxford University Pres, New York, 1994.
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